Current medical research and opinion
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Randomized Controlled Trial Multicenter Study
Saxagliptin versus glipizide as add-on therapy to metformin: assessment of hypoglycemia.
To compare characteristics of hypoglycemic episodes in patients with type 2 diabetes receiving saxagliptin or glipizide add-on therapy to metformin. ⋯ Saxagliptin + metformin was associated with fewer patients reporting hypoglycemia and fewer and less severe hypoglycemic events in those experiencing hypoglycemia compared with glipizide + metformin. ClinicalTrials.gov registration number: NCT00575588.
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Multicenter Study Clinical Trial Observational Study
Weight loss through adjustable gastric banding and improvement in daytime sleepiness: 2 year interim results of APEX study.
Obesity is one factor associated with an increased risk of obstructive sleep apnea (OSA). This study reports the investigator-reported resolution or improvement of OSA and improvements in sleep-related quality of life (QOL) 2 years after surgical placement of the LAP-BAND AP * (LBAP) system. ⋯ These data support that surgically facilitated weight loss can improve sleep-related QOL and may result in resolution or improvement of OSA; the degree of weight loss may be related to these changes.