Current medical research and opinion
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Randomized Controlled Trial Multicenter Study
A randomized open label, parallel-group study to evaluate the hemodynamic effects of cafedrine/theodrenaline vs noradrenaline in the treatment of intraoperative hypotension after induction of general anesthesia: the 'HERO' study design and rationale.
Intraoperative arterial hypotension (IOH) is associated with poor patient outcome. This study aims to compare the hemodynamic effects of Cafedrine/Theodrenaline (C/T) and Noradrenaline (NA) for the treatment of hypotension in patients who develop IOH after anesthesia induction. ⋯ This clinical trial will yield evidence for marketing authorization of C/T applied as continuous infusion. Additionally, the effects of C/T compared to NA on cardiac index will be assessed. First results of the "HERO"-study are expected in 2024. DRKS identifier: DRKS00028589. EudraCT identifier: 2021-001954-76.