Revista clínica española
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Rev Clin Esp
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Revista clínica española · Dec 2020
Neutrophils as instigators of thrombosis: Beyond antimicrobial protection.
When activated, neutrophils release structures (NETs) composed of DNA, histones and granular proteins that provide an ideal matrix for platelet activation and coagulation mechanisms, thereby contributing to the pathogenesis of thrombosis in venous and arterial territories, as well as cancer-associated thrombosis. NETs play a key role in immunothrombosis, a term that describes the relationship between the immune response and coagulation.