Revista clínica española
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Revista clínica española · Jul 2005
[The use of suprarenal scintigraphy in the differential diagnosis of suprarenal incidentaloma].
To assess the usefulness of adrenal scintigraphy for clinical evaluation of adrenal incidentalomas, and its relation with pathological diagnosis and follow-up. ⋯ Detection of a lesion with no uptake in adrenal scintigraphy forces to carry out complementary explorations in order to rule out malignant pathology. A lesion with excessive uptake is indicative of a benign process and should be assessed with hormonal determinations.
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The importance of rhythmic activities in humans, and their influence on the diseases are underscored. Clinical chronology is fundamental in order to interpret the physiopathological basis of temporary variations. Knowing the variability of the biological processes also makes it possible improving the effect of drugs utilized and minimize their adverse effects. ⋯ One thinks about the mechanisms or factors that favor cardiovascular diseases, especially those related to the circadian variations of blood pressure. We also review the variations in the pharmacokinetics of the drugs used in the treatment of cardiovascular diseases, delving further into the analysis of its effects according to their administration schedule. We can conclude that the use of those drugs according to the chronological knowledge makes possible to achieve better results in the control of cardiovascular diseases, and a greater safety in its use.
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Revista clínica española · Apr 2005
Meta Analysis[Congestive heart failure in Spain: cost-effectiveness and cost-benefit analyses of treatment with beta-blockers].
Beta-blockers (BB) have proven to be effective in the treatment of congestive heart failure (CHF). This study is an economic analysis for the addition of BB to standard treatment of CHF. ⋯ Use of BB in the treatment of CHF is an effective and cost-effective alternative. Carvedilol is the most effective alternative, and bisoprolol the most cost-effective alternative and the drug with greater benefit-cost index.
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In this review the current situation of gene therapy is described in hematological diseases, immunological conditions, and cancer. In all of them, the principal objective of various approaches with gene therapy is transduction of therapeutic genes in most of target cells. ⋯ Consequently, vectors are one of the basic elements to optimize gene therapy approaches and protocols in view of the facts that we know that with liposomes less than 10% of cells are transduced, that retrovirus only infect cells in replication, and that adenovirus give rise to an important inflammatory response and a transitory transduction of the therapeutic gene. In addition recent approaches in cancer gene therapy with selective replication virus, suicidal genes, etc., are discussed.