Journal of critical care
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Journal of critical care · Feb 2014
Randomized Controlled TrialHeparin/N-acetylcysteine: An adjuvant in the management of burn inhalation injury: A study of different doses.
Nebulized heparin may reduce fibrin cast formation and reduce the degree of airway obstruction in burn inhalation injury. ⋯ Nebulized heparin 10,000 IU decreased lung injury scores and duration of mechanical ventilation but had no effect on length of ICU stay and mortality. Moreover, nebulized heparin 10,000 IU was safe and had no effect on coagulation parameters.
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Journal of critical care · Feb 2014
Randomized Controlled TrialMelatonin suppresses markers of inflammation and oxidative damage in a human daytime endotoxemia model.
Melatonin used as an exogenous drug has been documented to have potent antioxidant and anti-inflammatory effects in animal model. We aimed to examine the effect of melatonin in an experimental human sepsis model. ⋯ Melatonin administration before endotoxemia resulted in reduction of certain markers of inflammation and oxidative stress. Further studies are needed to clarify the role of melatonin in clinical setting.