Journal of critical care
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Journal of critical care · Jun 2019
Observational StudyA worldwide perspective of sepsis epidemiology and survival according to age: Observational data from the ICON audit.
To investigate age-related differences in outcomes of critically ill patients with sepsis around the world. ⋯ The odds for death in ICU patients with sepsis increased with age with the maximal rate of increase occurring between the ages of 71 and 77 years.
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Journal of critical care · Jun 2019
Randomized Controlled TrialThe effect of direct hemoperfusion with polymyxin B immobilized cartridge on meropenem in critically ill patients requiring renal support.
To evaluate the effect of direct hemoperfusion with polymyxin B immobilized cartridge (DHP-PMX) on meropenem pharmacokinetics in critically ill patients with sepsis requiring continuous venovenous hemofiltration (CVVH). ⋯ No significant effect of DHP-PMX on meropenem pharmacokinetics was observed among severe sepsis/septic shock patients during CVVH treatment.
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Journal of critical care · Jun 2019
Review Meta AnalysisWorldwide variation in Pseudomonas associated ventilator associated pneumonia. A meta-regression.
The objective here is to define the extent and possible reasons for geographic variation in Pseudomonas aeruginosa associated with Ventilator Associated Pneumonia (VAP). ⋯ Pseudomonas associated VAP incidence among reports from six geographic regions worldwide varies by less than twofold with some decline by year of publication. Trauma ICU admission is a significant factor underlying variations in incidence of VAP overall but not Pseudomonas associated VAP.
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Journal of critical care · Jun 2019
Multicenter Study Observational StudyHuman atrial natriuretic peptide for acute kidney injury in adult critically ill patients: A multicenter prospective observational study.
Acute kidney injury (AKI) is common in the intensive care unit (ICU). Selected clinical studies have implied human atrial natriuretic peptide (hANP) improves renal function; however, the treatment effects for AKI are unclear. ⋯ In critically ill patients with AKI, the treatment effect of hANP was not evident on dialysis-free survival in the ICU.
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Journal of critical care · Jun 2019
Association between strained ICU capacity and healthcare costs in Canada: A population-based cohort study.
Intensive care is resource intensive, with costs representing a substantial quantity of total hospitalization costs. Strained ICU capacity compromises care quality and adversely impacts outcomes; however, the association between strain and healthcare costs has not been explored. ⋯ Admissions to ICUs experiencing strain incur incremental costs, attributed to longer hospitalization and physician services.