Journal of critical care
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Journal of critical care · Jun 2019
Usefulness of qSOFA and SIRS scores for detection of incipient sepsis in general ward patients: A prospective cohort study.
To prospectively assess the diagnostic value of quick Sequential Organ Failure Assessment (qSOFA) and systemic inflammatory response syndrome (SIRS) scores for sepsis in ward patients with infections. ⋯ Neither SIRS score nor qSOFA score could serve as an ideal screening tool for early identification sepsis, whereas qSOFA score might help to identify patients with higher risk of poor clinical outcome.
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Journal of critical care · Jun 2019
Acute kidney injury following contrast media administration in the septic patient: A retrospective propensity-matched analysis.
To determine the risk for acute kidney injury (AKI) attributable to intravenous contrast media (CM) administration in septic patients. ⋯ Sepsis is a medical emergency proven to benefit from early diagnosis and rapid initiation of treatment, which is often aided by CECT. Our findings argue against withholding CM for fear of precipitating AKI in potentially septic patients.
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Journal of critical care · Jun 2019
Modification of sequential organ failure assessment score using acute kidney injury classification.
To assess the predictive validity of a modified Sequential Organ Failure Assessment (SOFA) score, of which the renal component was replaced with Kidney Disease Improving Global Outcomes (KDIGO) classification of Acute Kidney Injury (AKI). ⋯ The prognostic performance of KDIGO-based SOFA score was not superior but comparable to that of the original SOFA score.
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Journal of critical care · Jun 2019
Lung nitroxidative stress in mechanically-ventilated septic patients: A pilot study.
During sepsis and mechanical ventilation oxidative stress is generated by endothelial and inflammatory lung cells. Our main objective was to study pulmonary NO (nitric oxide) production and nitroxidative stress in mechanically-ventilated septic patients. ⋯ We conclude that during early phases of sepsis there is an enhanced lung nitroxidative stress due to an increase of NO production leading to secondary NO-derived oxidants, which promote protein nitration and lipid peroxidation.