Journal of critical care
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Journal of critical care · Aug 2019
Observational StudyChanges of plasma acetylcholine and inflammatory markers in critically ill patients during early enteral nutrition: A prospective observational study.
Acetylcholine (Ach) is the key anti-inflammatory transmitter in the cholinergic anti-inflammatory pathway. In this study, critically ill patients treated with early enteral nutrition (EEN) were observed to explore whether EEN affected Ach levels and inflammation. ⋯ The administration of EEN to critically ill patients contributed to the increased plasma Ach levels and decreased inflammatory markers. The effect of EEN on Ach levels is partially attributed to the increase in CCK levels. Elevated plasma Ach levels indicate a better prognosis. Clinical trials identifier: NCT03612206.
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Journal of critical care · Aug 2019
Review Meta AnalysisEffects of post-ICU follow-up on subject outcomes: A systematic review and meta-analysis.
The present systematic review and meta-analysis aimed to synthesize data on subject outcomes associated with post-ICU follow-up. ⋯ Post-ICU follow-up may improve depression symptoms and mental health-related quality of life in the short term for models focusing on physical therapy and PTSD symptoms in the medium term for models focusing on psychological or medical management interventions.
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Journal of critical care · Aug 2019
Multicenter Study Observational StudyThe furosemide stress test for prediction of worsening acute kidney injury in critically ill patients: A multicenter, prospective, observational study.
To validate the furosemide stress test (FST) for predicting the progression of acute kidney injury (AKI). ⋯ In ICU patients without severe CKD with mild AKI, a UFR of less than 200mls in the first 2 h after an FST is predictive of progression to stage III AKI. Future studies should focus on incorporating a FST as part of a clinical decision tool for further management of critically ill patients with AKI.
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Journal of critical care · Aug 2019
Review Meta AnalysisUtility of pleural effusion drainage in the ICU: An updated systematic review and META-analysis.
The effects on the respiratory or hemodynamic function of drainage of pleural effusion on critically ill patients are not completely understood. First outcome was to evaluate the PiO2/FiO2 (P/F) ratio before and after pleural drainage. ⋯ Pleural effusion drainage improves oxygenation of critically ill patients. It is a safe procedure. Further studies are needed to assess the hemodynamic effects of pleural drainage.