Journal of critical care
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Journal of critical care · Feb 2023
Randomized Controlled TrialThe clinical and paraclinical effectiveness of four-hour infusion vs. half-hour infusion of high-dose ampicillin-sulbactam in treatment of critically ill patients with sepsis or septic shock: An assessor-blinded randomized clinical trial.
This study was conducted to determine whether critically ill patients admitted to the intensive care unit (ICU) with sepsis and septic shock may benefit from extended infusion of ampicillin/sulbactam compared with those receiving intermittent infusion. ⋯ These data should be replicated in larger clinical trials before providing any recommendation in favor of this method of administration in clinical practice.
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Journal of critical care · Feb 2023
Admission serum sodium and osmolarity are not associated with the occurrence or outcomes of acute respiratory distress syndrome in critically ill.
Previous studies suggested that hypernatremia or hyperosmolarity may have protective effects in lung injury. We hypothesized that hypernatremia and/or hyperosmolarity would prevent ARDS. ⋯ Admission serum sodium or serum osmolarity were not associated with the occurrence or outcomes of ARDS in ICU.
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Journal of critical care · Feb 2023
Observational StudyAssociation between metformin and survival outcomes in in-hospital cardiac arrest patients with diabetes.
Metformin has shown cardioprotective and neuroprotective effects in cardiac arrest and ischemia-reperfusion injury animal models. Therefore, this study aimed to determine the association between diabetes medication and survival outcomes in in-hospital cardiac arrest (IHCA) patients with type 2 DM (T2DM). ⋯ In IHCA patients with T2DM, administration of metformin within 24 h before IHCA was independently associated with survival to discharge.