Journal of critical care
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Journal of critical care · Oct 2021
Randomized Controlled TrialEvolution of practice patterns in the management of acute respiratory distress syndrome: A secondary analysis of two successive randomized controlled trials.
We sought to examine changes in acute respiratory distress syndrome (ARDS) management over a 12-year period of two successive randomized trials. ⋯ Clear trends were apparent in tidal volume, airway pressures, ventilator modes, adjuncts and rescue therapies. With the exception of prone positioning, and outside the context of rescue therapy, these trends appear consistent with the evolving literature on ARDS management.
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Journal of critical care · Jun 2021
Randomized Controlled TrialAlbumin replacement therapy in immunocompromised patients with sepsis - Secondary analysis of the ALBIOS trial.
The best fluid replacement strategy and the role of albumin in immunocompromised patients with sepsis is unclear. ⋯ Albumin replacement during the ICU stay, as compared with crystalloids alone, did not affect clinical outcomes in a cohort of immunocompromised patients with sepsis.
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Journal of critical care · Jun 2021
Randomized Controlled TrialThe efficacy of the WhisperFlow CPAP system versus high flow nasal cannula in patients at risk for postextubation failure: A Randomized controlled trial.
Compare the efficacy(reintubation rate) between a high-flow nasal cannula(HFNC) and the WhisperFlow CPAP system in patients at risk for postextubation failure. ⋯ We are unable to demonstrate a reduction in postextubation respiratory failure in at risk patients with the use of HFNC compared with the WhisperFlow CPAP system probably because small sample size, but HFNC was better tolerated.
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Journal of critical care · Apr 2021
Randomized Controlled Trial Multicenter StudyEffect of non-sedation on physical function in survivors of critical illness - A substudy of the NONSEDA randomized trial.
Critical illness impairs physical function. The NONSEDA trial was a multicenter randomized trial, assessing non-sedation versus sedation during mechanical ventilation. The aim of this sub-study was to assess the effect of non-sedation on physical function. ⋯ Non-sedation did not lead to improved quality of life regarding physical function or better function in activities of everyday living. Non-sedated patients had a better physical recovery at ICU discharge.
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Journal of critical care · Apr 2021
Randomized Controlled TrialThe impact of a cardiopulmonary resuscitation video on reducing surrogates' anxiety: A pilot randomized controlled trial.
To test the primary hypothesis that a CPR video will reduce ICU patients' surrogates' anxiety when deciding code status, as measured by the Hamilton Anxiety Rating (HAM-A) Scale, as compared to the no video group. ⋯ CPR video used to supplement ICU team-led code status discussions reduced surrogates' anxiety, as compared to no video.