Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Randomized Controlled Trial Comparative Study Clinical Trial
Prophylactic antiemetic therapy with granisetron-droperidol combination in patients undergoing laparoscopic cholecystectomy.
A relatively high incidence of postoperative nausea and vomiting (PONV) occurs in patients undergoing laparoscopic cholecystectomy. This study was undertaken to compare the efficacy of granisetron-droperidol combination with each drug alone for the prevention of PONV after laparoscopic cholecystectomy. ⋯ Granisetron-droperidol combination is more effective than each antiemetic alone in the prevention of PONV after laparoscopic cholecystectomy.
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison between epidural infusion of fentanyl/bupivacaine and morphine/bupivacaine after orthopaedic surgery.
To compare epidural infusions of bupivacaine-fentanyl and bupivacaine-morphine mixtures for postoperative pain relief after total hip replacement. ⋯ Continuous epidural infusion of bupivacaine-morphine or bupivacaine-fentanyl mixtures provided similar pain relief. Patients receiving morphine showed a more marked decrease in SpO2 than those receiving fentanyl. However, the average SpO2 remained > 90% in both groups.
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Randomized Controlled Trial Comparative Study Clinical Trial
The effectiveness of low dose tranexamic acid in primary cardiac surgery.
This randomized controlled clinical trial compared three doses of tranexamic acid (TA) in primary cardiac surgery in terms of blood loss and transfusion requirements. ⋯ This study demonstrates the equivalency of the three doses of TA in primary cardiac surgical procedures. The use of low dose (20 mg.kg-1) TA results in comparable outcomes, without additional complications.
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Randomized Controlled Trial Comparative Study Clinical Trial
Dissociation between haemodynamics and sympathetic activation during anaesthetic induction with desfluranes.
To compare the simultaneous haemodynamic effects, sympathetic activation and cardiac risks associated with desflurane used in a balanced technique, with those of isoflurane anaesthesia. ⋯ Desflurane differs from isoflurane in that sympathetic stimulation persisted despite blunting of potential hyperdynamic haemodynamic responses by narcotic and beta blockade. However, this sympathetic activation did not appear to increase cardiac risks.
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Randomized Controlled Trial Comparative Study Clinical Trial
Pharmacokinetics of doxacurium during normothermic and hypothermic cardiopulmonary bypass surgery.
To compare the pharmacokinetic behaviour of doxacurium in patients undergoing normothermic or hypothermic cardiopulmonary bypass (CPB) for coronary artery bypass graft surgery. ⋯ The elimination rate of doxacurium during normothermic CPB is faster than that in hypothermic CPB.