Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Comparative Study
Analgesic effects of systemic midazolam: comparison with intrathecal administration.
Midazolam has antinociceptive effects when administered intrathecally, while its effects associated with systemic administration remain controversial. In the present study, the antinociceptive properties of systemically vs intrathecally administered midazolam were investigated in a rat model of thermal and inflammatory pain. ⋯ Systemically administered midazolam induced antinociception for inflammatory pain only, while intrathecal administration elicited antinociceptive effects on both acute thermal and inflammatory-induced pain.