Canadian journal of anaesthesia = Journal canadien d'anesthésie
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Review Meta Analysis
Topical application of antifibrinolytic drugs for on-pump cardiac surgery: a systematic review and meta-analysis.
This systematic review aimed to evaluate the efficacy and safety of topical application of antifibrinolytic drugs to reduce postoperative bleeding and transfusion requirements in patients undergoing on-pump cardiac surgery. ⋯ This review suggests that topical application of antifibrinolytics can reduce postoperative bleeding and transfusion requirements in patients undergoing on-pump cardiac surgery. These promising findings need to be confirmed by more trials with large sample size using patient-related outcomes and more assessments regarding the systemic absorption of the medications.
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Randomized Controlled Trial
Sympathectomy-mediated vasodilatation: a randomized concentration ranging study of epidural bupivacaine.
We tested the hypothesis that the development of sympathectomy-mediated vasodilatation is dependent on the concentration rather than the dose of epidural local anesthetic administered. ⋯ Our observations suggest that drug concentration is more important than drug dose in determining the degree of sympathectomy following lumbar epidural local anesthesia.