The Pediatric infectious disease journal
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Pediatr. Infect. Dis. J. · May 2012
ReviewThe role of Panton-Valentine leukocidin in Staphylococcus aureus musculoskeletal infections in children.
Infections caused by Panton-Valentine leukocidin (PVL)-producing strains of Staphylococcus aureus have been reported with increasing frequency. However, the role of PVL in the pathogenesis of invasive staphylococcal infection is controversial. ⋯ A number of recent reports describe severe complications associated with PVL-producing strains in musculoskeletal infections. This review summarizes the current evidence on the influence of PVL on musculoskeletal infections caused by S. aureus in children and highlights areas of uncertainty relating to management.