Critical care medicine
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Critical care medicine · Feb 1996
Clinical diagnostic criteria of the adult respiratory distress syndrome in the intensive care unit.
To determine the use of commonly used diagnostic criteria for adult/acute respiratory distress syndrome (ARDS), evaluate physiologic variables of most value in diagnosing ARDS, and assess the frequency of newly diagnosed ARDS. ⋯ A wide range of diagnostic criteria are utilized by clinicians in the diagnosis of ARDS.
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Critical care medicine · Feb 1996
Multicenter StudyAcute renal failure in intensive care units--causes, outcome, and prognostic factors of hospital mortality; a prospective, multicenter study. French Study Group on Acute Renal Failure.
To assess the causes, the prognostic factors, and the outcome of patients with severe acute renal failure. ⋯ The hospital mortality rate of patients with severe acute renal failure in patients requiring intensive care remains high. In order to compare patient groups in further trials concerning acute renal failure, recorded characteristics of the population should include age, previous health status, disease characteristics (initial or delayed acute renal failure, oliguria, sepsis), and the severity of the illness as assessed by physiologic scoring systems recorded at the time of study inclusion.
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Critical care medicine · Feb 1996
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialLorazepam and midazolam in the intensive care unit: a randomized, prospective, multicenter study of hemodynamics, oxygen transport, efficacy, and cost.
To evaluate and compare the clinical efficacy, impact on hemodynamic and oxygen transport variables, safety profiles, and cost efficiency of sedation and anxiolysis with lorazepam vs. continuous infusion of midazolam in critically ill, intensive care unit patients. ⋯ Sedation and anxiolysis with lorazepam and midazolam in critically ill patients is safe and clinically effective. Hemodynamic and oxygen transport variables are similarly affected by both drugs. The dose of midazolam required for sedation is much larger than the dose of lorazepam required for sedation, and midazolam is therefore less cost-efficient.
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Critical care medicine · Feb 1996
Comparative Study Clinical Trial Controlled Clinical TrialAdministration of an antibody to E-selectin in patients with septic shock.
To determine the safety and pharmacokinetics of a murine monoclonal antibody to E-selectin in patients with newly developed septic shock. ⋯ This pilot study indicates that this antibody to E-selectin appears to be safe and may represent a promising form of therapy in septic shock.