Critical care medicine
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The origins of trauma systems in the United States date to the 1960s when physicians returning from wars abroad realized that lessons learned from managing military casualties could be applied to civilian traumatic injury. Over the next several decades, trauma centers and then trauma systems began to be developed in an attempt to improve prehospital and acute care for these patients. Although studies of trauma system effectiveness are fraught with methodologic difficulties, several types of studies (panel reviews of preventable deaths, registry studies, and population-based studies), suggest that there may be improvements in mortality when trauma systems are established. ⋯ Pediatric trauma systems have by necessity developed within the "adult" systems in place. The history of pediatric system development and studies assessing outcomes are also discussed. Continued system development, assessment, and educational efforts about how childhood injuries are different are essential to combat this leading killer of children.
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Critical care medicine · Nov 2002
Multicenter StudyEffect of an education program aimed at reducing the occurrence of ventilator-associated pneumonia.
The purpose of the study was to determine whether an education initiative could decrease the hospital rate of ventilator-associated pneumonia. ⋯ A focused education intervention can dramatically decrease the incidence of ventilator-associated pneumonia. Education programs should be more widely employed for infection control in the intensive care unit setting and can lead to substantial decreases in cost and patient morbidity attributed to hospital-acquired infections.
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Critical care medicine · Nov 2002
Multicenter StudyEffects of severity of illness on resource use by survivors and nonsurvivors of severe sepsis at intensive care unit admission.
To determine the relationship between severity of illness and length of stay for survivors and nonsurvivors of severe sepsis at intensive care unit admission. ⋯ Differences in length of stay between sepsis survivors and nonsurvivors were related to severity of illness. Thus, the potential economic effect of a new therapy for sepsis would depend, in part, on which particular patients, in terms of severity of illness, were enrolled. New therapies targeted to decrease mortality rate in patients with severe sepsis can potentially lead to the overall cost of care being neutral or increased depending on the severity levels of patients included in clinical trials.
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Critical care medicine · Nov 2002
Randomized Controlled Trial Clinical TrialCardiac and respiratory effects of continuous positive airway pressure and noninvasive ventilation in acute cardiac pulmonary edema.
Continuous positive airway pressure (CPAP) is considered an effective nonpharmacologic method of treating patients with severe acute cardiogenic pulmonary edema. However, we hypothesized that bilevel noninvasive positive-pressure ventilation (NPPV), which combines both inspiratory pressure support and positive expiratory pressure, would unload the respiratory muscles and improve cardiac and hemodynamic function more effectively than CPAP. ⋯ This study demonstrates that NPPV was more effective at unloading the respiratory muscles than CPAP in acute cardiogenic pulmonary edema. In addition, NPPV and 10 cm H2O CPAP produced a reduction in right and left ventricular preload, which suggests an improvement in cardiac performance.
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Critical care medicine · Nov 2002
Multicenter StudyPopulation-based assessment of intensive care unit-acquired bloodstream infections in adults: Incidence, risk factors, and associated mortality rate.
Nosocomial bloodstream infections have been extensively investigated, but relatively few studies have specifically evaluated the epidemiology of intensive care unit-acquired bloodstream infections. The study objective was to define the incidence, risk factors, microbiology, and clinical outcomes of intensive care unit-acquired bloodstream infections. ⋯ One patient in 20 admitted to Calgary Health Region intensive care units acquires bloodstream infection and suffers longer intensive care unit stay and increased mortality rates. In our region, multiple antibiotic-resistant organisms are uncommon causes of bloodstream infections, suggesting that it may be safe to use narrower spectrum empirical treatment regimens than current guidelines recommend.