Critical care medicine
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Critical care medicine · May 2002
Multicenter StudyAssociation between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate.
Genetic differences in immune responses may affect susceptibility to and outcome of septic shock. CD14 seems to be an important part of the innate immune system, initiating antimicrobial response. We evaluated the frequency of a recently discovered CD14 promoter gene polymorphism (C to T transition at base pair -159) among patients with septic shock compared with those in a control group. ⋯ The C-159T polymorphism affects susceptibility to septic shock and seems to be a new genetic risk factor for death.