Critical care medicine
-
Critical care medicine · Jul 2003
Effect of ventilatory variables on gas exchange and hemodynamics during total liquid ventilation in a rat model.
To investigate the settings necessary to achieve maximum gas exchange and pulmonary function while minimizing effects on cardiovascular hemodynamics during total liquid ventilation with a pressure-limited, time-cycled ventilator in a rat model. ⋯ These data demonstrate the feasibility of performing total liquid ventilation in rodents. A balance must be identified where gas exchange is optimal yet hemodynamics are least affected. In the specific system studied, an inspiratory/expiratory ratio of 1:2.5 and respiratory rate of 6.8 breaths/min appeared to provide optimal gas exchange while minimizing the effects on hemodynamics.
-
Critical care medicine · Jul 2003
Comparative StudyFenoldopam--but not dopamine--selectively increases gastric mucosal oxygenation in dogs.
To compare the effects of fenoldopam and dopamine on gastric mucosal and systemic oxygenation, and to identify the receptors involved. ⋯ Fenoldopam dose-dependently increased microvascular oxygenation of the gastric mucosa without changing systemic oxygen transport, i.e., this drug acted selectively on the splanchnic mucosa. The increase in gastric mucosal oxygenation was mediated by DA(1)-receptors. In contrast, dopamine markedly increased systemic oxygen transport, but did not affect microvascular oxygenation of gastric mucosa. This lacking effect on gastric mucosal oxygenation was not caused by alpha(1)-mediated vasoconstriction. The regional effects of both catecholamines could not be deduced from systemic hemodynamics and oxygenation.
-
Critical care medicine · Jul 2003
Comment Letter Comparative StudyDifferences may have contributed to differences noted in respiratory complications.
-
Critical care medicine · Jul 2003
Comparative StudyEffect of helium-oxygen (heliox) gas mixtures on the function of four pediatric ventilators.
To evaluate the effects of helium on the function of four ventilators commonly used in pediatrics: the Bird VIP, Bird VIP Gold, Servo 300, and Servo 900C. ⋯ The addition of helium has a significant effect on Fio(2) delivery, displayed inspiratory V(T), and actual delivered V(T) during both volume- and pressure-controlled ventilation in four ventilators commonly used in pediatric critical care. These effects are both ventilator specific and ventilation mode specific, mandating vigilance during helium ventilation in clinical practice.