Critical care medicine
-
Critical care medicine · Jul 2003
Randomized Controlled Trial Comparative Study Clinical TrialFluconazole improves survival in septic shock: a randomized double-blind prospective study.
To demonstrate whether fluconazole reduces multiple organ failure and mortality in early septic shock (<24 hrs). ⋯ The development of organ failure and mortality in septic shock was significantly reduced by fluconazole given intravenously. The mechanism of action of fluconazole in reducing multiple organ dysfunction in this group of patients may be attributed to the ability of fluconazole to increase recruitment, improve bactericidal activity of neutrophils, and to contain microorganisms locally.