Critical care medicine
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Critical care medicine · Oct 2005
Multicenter Study Clinical TrialCardiovascular response to dopamine and early prediction of outcome in septic shock: a prospective multiple-center study.
To compare mortality rates between dopamine-sensitive (Dopa-S) and dopamine-resistant (Dopa-R) septic shock patients, the latter group defined by a mean arterial pressure <70 mm Hg despite the use of 20 mug/kg/min dopamine. ⋯ Dopamine sensitivity is associated with decreased mortality rate. Early recognition of dopamine resistant septic shock could allow for better screening of patients with an ominous prognosis.
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Critical care medicine · Oct 2005
Multicenter StudyDrotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment.
To provide further evidence for the efficacy and safety of drotrecogin alfa (activated) treatment in severe sepsis. ⋯ ENHANCE provides supportive evidence for the favorable benefit/risk ratio observed in PROWESS and suggests that more effective use of drotrecogin alfa (activated) might be obtained by initiating therapy earlier.