Critical care medicine
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Critical care medicine · Feb 2006
Increases in tissue Pco2 during circulatory shock reflect selective decreases in capillary blood flow.
Tissue Pco2 reflects metabolic alterations due to circulatory failure during circulatory shock. This study addresses simultaneous changes in gastric and buccal tissue Pco2 with changes in microcirculatory blood flow in a rat model of circulatory shock induced by cecal ligation and puncture. ⋯ These observations suggest that microcirculatory failure in capillaries appears as an early defect in close association with anaerobic metabolism during progression of circulatory shock in an animal model of septic peritonitis.
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Critical care medicine · Feb 2006
Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis.
We have documented an impaired neutrophil migration toward the infectious focus in severe sepsis. This phenomenon appears to be mediated by nitric oxide, the release of which is stimulated by circulating inflammatory cytokines released by immune cells after stimulation by bacteria and/or their products. Toll-like receptor 4 (TLR4) is the major recognition receptor for lipopolysaccharide, a component of Gram-negative bacterial cell walls. In the present study, we investigated whether TLR4 is involved in the failure of neutrophil migration in mice subjected to polymicrobial or Gram-negative sepsis. ⋯ These results highlight the harmful role of TLR4 signaling in polymicrobial severe sepsis.
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Critical care medicine · Feb 2006
Editorial CommentSeverity of illness scoring in fulminant hepatic failure.