Critical care medicine
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Critical care medicine · Feb 2006
Review Meta AnalysisOxime therapy and outcomes in human organophosphate poisoning: an evaluation using meta-analytic techniques.
The status of oximes in human organophosphate poisoning is controversial. This analysis compares the outcomes of therapy with or without oximes. ⋯ Based on the current available data on human organophosphate poisoning, oxime was associated with either a null effect or possible harm. The lack of current prospective randomized controlled trials, with appropriate patient stratification, mandates ongoing assessment of the role of oximes in organophosphate poisoning.