Critical care medicine
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Critical care medicine · Jun 2007
Randomized Controlled Trial Multicenter Study Comparative StudyADDRESS (ADministration of DRotrecogin alfa [activated] in Early stage Severe Sepsis) long-term follow-up: one-year safety and efficacy evaluation.
To demonstrate that drotrecogin alfa (activated) has an acceptable safety profile 1 yr from randomization. ⋯ No increased risk of death or evidence of harm at 1 yr was associated with drotrecogin alfa (activated) administration in patients with severe sepsis at lower risk of death.
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Critical care medicine · Jun 2007
Multicenter StudyCombination antibiotic therapy improves survival in patients with community-acquired pneumonia and shock.
To assess whether combination antibiotic therapy improves outcome of severe community-acquired pneumonia in the subset of patients with shock. ⋯ Combination antibiotic therapy does not seem to increase ICU survival in all patients with severe community-acquired pneumonia. However, in the subset of patients with shock, combination antibiotic therapy improves survival rates.