Critical care medicine
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Critical care medicine · Jul 2008
Randomized Controlled Trial Multicenter StudyA randomized trial of daily awakening in critically ill patients managed with a sedation protocol: a pilot trial.
Protocolized sedation (PS) and daily sedative interruption (DI) in critically ill patients have both been shown to shorten the durations of mechanical ventilation (MV) and intensive care unit (ICU) stay. Our objective was to determine the safety and feasibility of a randomized trial to determine whether adults managed with both PS + DI have a shorter duration of MV than patients managed with PS alone. ⋯ This pilot trial comparing PS vs. PS + DI confirmed the safety and acceptability of the sedation protocol and DI, and guided important modifications to the protocol, thus enhancing the feasibility of a future multicenter trial. This trial was not designed to detect small but significant differences in clinically important outcomes.
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Critical care medicine · Jul 2008
Randomized Controlled Trial Multicenter StudyMulticenter, randomized, placebo-controlled study of the nitric oxide scavenger pyridoxalated hemoglobin polyoxyethylene in distributive shock.
To assess the safety and efficacy of the hemoglobin-based nitric oxide scavenger, pyridoxalated hemoglobin polyoxyethylene (PHP), in patients with distributive shock. ⋯ PHP is a hemodynamically active nitric oxide scavenger. The role of PHP in distributive shock remains to be determined.
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Critical care medicine · Jul 2008
Randomized Controlled TrialAerosolized antibiotics and ventilator-associated tracheobronchitis in the intensive care unit.
In critically ill intubated patients, signs of respiratory infection often persist despite treatment with potent systemic antibiotics. ⋯ In critically ill patients with ventilator-associated tracheobronchitis, AA decrease VAP and other signs and symptoms of respiratory infection, facilitate weaning, and reduce bacterial resistance and use of systemic antibiotics.