Critical care medicine
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Critical care medicine · Nov 2012
Randomized Controlled Trial Multicenter StudyA multicenter, phased, cluster-randomized controlled trial to reduce central line-associated bloodstream infections in intensive care units*.
To determine the causal effects of an intervention proven effective in pre-post studies in reducing central line-associated bloodstream infections in the intensive care unit. ⋯ This study demonstrated a causal relationship between the multifaceted intervention and the reduced central line-associated bloodstream infections. Both groups decreased infection rates after implementation and sustained these results over time, replicating the results found in previous, pre-post studies of this multifaceted intervention and providing further evidence that most central line-associated bloodstream infections are preventable.