Critical care medicine
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Critical care medicine · Mar 2016
Multicenter Study Comparative StudyDoes IV Iron Induce Plasma Oxidative Stress in Critically Ill Patients? A Comparison With Healthy Volunteers.
To compare the oxidative stress induced by IV iron infusion in critically ill patients and in healthy volunteers. ⋯ In our observation, IV iron infusion does not induce more nontransferrin bound iron, lipid, or protein oxidation in patients compared with volunteers, despite higher inflammation, oxidative stress, and hepcidin levels and lower antioxidant at baseline. In contrary, iron induces a greater decrease in antioxidant, compatible with higher oxidative stress in volunteers than in critically ill patients.