Critical care medicine
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Critical care medicine · Sep 2018
Randomized Controlled TrialImpact of Very Early Physical Therapy During Septic Shock on Skeletal Muscle: A Randomized Controlled Trial.
As the catabolic state induced by septic shock together with the physical inactivity of patients lead to the rapid loss of muscle mass and impaired function, the purpose of this study was to test whether an early physical therapy during the onset of septic shock regulates catabolic signals and preserves skeletal muscle mass. ⋯ Early physical therapy during the first week of septic shock is safe and preserves muscle fiber cross-sectional area.
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Critical care medicine · Sep 2018
Randomized Controlled Trial Multicenter StudyPrevention of Nosocomial Infections in Critically Ill Patients With Lactoferrin: A Randomized, Double-Blind, Placebo-Controlled Study.
To obtain preliminary evidence for the efficacy of lactoferrin as a preventative measure for nosocomial infections and inform the conduct of a definitive study. ⋯ Lactoferrin did not improve the primary outcome of antibiotic-free days, nor any of the secondary outcomes. Our data do not support the conduct of a larger phase 3 trial.
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Critical care medicine · Sep 2018
Randomized Controlled TrialExploratory Application of Neuropharmacometabolomics in Severe Childhood Traumatic Brain Injury.
To employ metabolomics-based pathway and network analyses to evaluate the cerebrospinal fluid metabolome after severe traumatic brain injury in children and the capacity of combination therapy with probenecid and N-acetylcysteine to impact glutathione-related and other pathways and networks, relative to placebo treatment. ⋯ This proof-of-concept neuropharmacometabolomics assessment reveals alterations in known and previously unidentified metabolic pathways and supports therapeutic target engagement of the combination of probenecid and N-acetylcysteine treatment after severe traumatic brain injury in children.
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Critical care medicine · Sep 2018
Randomized Controlled TrialEconomic Evaluation of a Patient-Directed Music Intervention for ICU Patients Receiving Mechanical Ventilatory Support.
Music intervention has been shown to reduce anxiety and sedative exposure among mechanically ventilated patients. Whether music intervention reduces ICU costs is not known. The aim of this study was to examine ICU costs for patients receiving a patient-directed music intervention compared with patients who received usual ICU care. ⋯ Patient-directed music intervention is cost-effective for reducing anxiety in mechanically ventilated ICU patients.