Critical care medicine
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Critical care medicine · Dec 2023
Observational StudyEarly, Persistent Lymphopenia Is Associated With Prolonged Multiple Organ Failure and Mortality in Septic Children.
Sepsis-associated immune suppression correlates with poor outcomes. Adult trials are evaluating immune support therapies. Limited data exist to support consideration of immunomodulation in pediatric sepsis. We tested the hypothesis that early, persistent lymphopenia predicts worse outcomes in pediatric severe sepsis. ⋯ Children with severe sepsis and persistent lymphopenia are at risk of prolonged MODS or PICU mortality. This evidence supports testing therapies for pediatric severe sepsis patients risk-stratified by early, persistent lymphopenia.
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Critical care medicine · Dec 2023
Editorial Comment Meta AnalysisDoes CytoSorb Pose Unique Challenges to Pooled Estimates in Meta-Analysis?