Critical care medicine
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Critical care medicine · Feb 2018
Retraction Of PublicationSevere Burnout Is Common Among Critical Care Physician Assistants: Retraction.
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Critical care medicine · Nov 2017
Retracted PublicationSevere Burnout Is Common Among Critical Care Physician Assistants.
To determine the prevalence of and risk factors for burnout among critical care medicine physician assistants. ⋯ Severe burnout is common in critical care medicine physician assistants. Higher patient-to-critical care medicine physician assistant ratios and provision of futile care are risk factors for severe burnout.
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Critical care medicine · Mar 2012
Retracted PublicationProtective effects of melanocortins on short-term changes in a rat model of traumatic brain injury*.
Treatment for traumatic brain injury remains elusive despite compelling evidence from animal models for a variety of therapeutic targets. Melanocortins have established neuroprotective effects against experimental ischemic stroke. We investigated whether melanocortin treatment of traumatic brain injury induces neuroprotection and promotes functional recovery. ⋯ Our data indicate that melanocortins protect against traumatic brain injury, in a broad time window and through activation of MC4 receptors, by counteracting the main traumatic brain injury-related mechanisms of damage. These findings could have major clinical implications.
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Critical care medicine · May 2011
Comparative Study Retracted PublicationMelanocortin 4 receptor stimulation decreases pancreatitis severity in rats by activation of the cholinergic anti-inflammatory pathway.
Acute pancreatitis is an inflammatory condition that may lead to multisystemic organ failure. Melanocortin peptides have been successfully used in experimental models of organ failure and shock, and their protective effect occurs through the activation of a vagus nerve-mediated cholinergic anti-inflammatory pathway by acting at brain melanocortin 4 receptors. In the light of these observations, we studied the effects of the selective melanocortin 4 receptor agonist RO27-3225 in an experimental model of cerulein-induced pancreatitis. ⋯ Our data show that melanocortin 4 receptor agonists reduce pancreatitis severity through the activation of the cholinergic anti-inflammatory pathway. These findings could be of particular interest in the clinical setting.