The Journal of head trauma rehabilitation
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J Head Trauma Rehabil · Sep 2014
Randomized Controlled TrialEffectiveness of amantadine hydrochloride in the reduction of chronic traumatic brain injury irritability and aggression.
Following traumatic brain injury (TBI), individuals may experience chronic problems with irritability or aggression, which may need treatment to minimize the negative impact on their relationships, home life, social interactions, community participation, and employment ⋯ : Amantadine 100 mg every morning and at noon appears an effective and safe means of reducing frequency and severity of irritability and aggression among individuals with TBI and sufficient creatinine clearance.