Epilepsy research
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Randomized Controlled Trial Multicenter Study Comparative Study
A comparison of pregabalin, lamotrigine, and placebo as adjunctive therapy in patients with refractory partial-onset seizures.
This study assessed the comparative efficacy of pregabalin for refractory partial seizures. ⋯ Pregabalin was demonstrated to be noninferior to lamotrigine in the treatment of refractory partial seizures. Overall conclusions were complicated by an unusually large and heterogeneous placebo response.