Journal of Korean medical science
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J. Korean Med. Sci. · Sep 2023
Factors Associated With the Development and Severity of Polycystic Liver in Patients With Autosomal Dominant Polycystic Kidney Disease.
Factors related to the development and severity of polycystic liver disease (PLD) have not been well established. We aimed to evaluate the genetic and epidemiologic risk factors of PLD in patients with autosomal dominant polycystic kidney disease (ADPKD). ⋯ Hepatic involvement in ADPKD could be related to kidney manifestations and genetic variants including PKD1-PT or PKD2. Monitoring hemoglobin and ALP and evaluating the genetic variants might help predict severe PLD.
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J. Korean Med. Sci. · Sep 2023
ReviewTriglyceride-Rich Lipoproteins and Remnant Cholesterol in Cardiovascular Disease.
Despite the well-established benefits of statin treatments in lowering low-density lipoprotein cholesterol (LDL-C), a significant residual risk for atherosclerotic cardiovascular disease (ASCVD) remains. Triglycerides (TGs) have long been recognized as potential residual risk factors in this context, but recent studies now disclose the substantial role of TG-rich lipoproteins (TRLs) and cholesterol components of metabolized TRLs (commonly referred to as remnant cholesterol) in atherogenesis, not just TGs alone. Evidence derived through diverse sources, including preclinical studies of pathogenic mechanisms, epidemiologic investigations, and genetic research, has consistently supported the considerable contribution of TRLs and remnant cholesterol in predicting occurrences of ASCVD. ⋯ However, routine clinical testing for remnant cholesterol and TRLs is still in question, necessitating further research into appropriate treatment plans if levels are elevated. New therapies targeting proteins in TG metabolic pathways, particularly angiopoietin-like protein 3 and apolipoprotein C-III, have shown potential advantages in patients with mild-to-moderate hypertriglyceridemia by reducing blood levels of TGs and remnant cholesterol. The aim of this review is to summarize existing evidence linking elevated TRLs and remnant cholesterol with development of ASCVD and to explore additional guidance for clinical therapy.
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J. Korean Med. Sci. · Sep 2023
Multicenter StudyThe Effect of Vanishing Twin on First- and Second-Trimester Maternal Serum Markers and Nuchal Translucency: A Multicenter Prospective Cohort Study.
The purpose of this study was to evaluate the effect of vanishing twin (VT) on maternal serum marker concentrations and nuchal translucency (NT). ⋯ VT can be considered as an adjustment factor for risk assessment in the second-trimester serum screening test.
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J. Korean Med. Sci. · Sep 2023
Uric Acid and Risk of Cardiovascular Disease and Mortality: A Longitudinal Cohort Study.
This study aimed to examine the association of serum uric acid levels with incident cardiovascular disease and mortality in Korean adults without gout. ⋯ A graded association was noted between serum uric acid levels and cardiovascular risk, suggesting that higher uric acid levels may adversely affect cardiovascular health and survival in individuals without gout.
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J. Korean Med. Sci. · Sep 2023
GPTZero Performance in Identifying Artificial Intelligence-Generated Medical Texts: A Preliminary Study.
With emergence of chatbots to help authors with scientific writings, editors should have tools to identify artificial intelligence-generated texts. GPTZero is among the first websites that has sought media attention claiming to differentiate machine-generated from human-written texts. ⋯ GPTZero has a low false-positive (classifying a human-written text as machine-generated) and a high false-negative rate (classifying a machine-generated text as human-written).