Journal of clinical pharmacy and therapeutics
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Randomized Controlled Trial Multicenter Study Comparative Study
Population pharmacokinetics of ABT-594 in subjects with diabetic peripheral neuropathic pain.
ABT-594 is a non-opioid, non-NSAID analgesic. The objective of this work was to characterize the population pharmacokinetics of ABT-594 in subjects with neuropathic pain. ⋯ A population pharmacokinetic model was developed to characterize ABT-594 concentrations in subjects with neuropathic pain. As ABT-594 is primarily eliminated as unchanged drug in the urine, creatinine clearance and age were significant covariates of clearance with creatinine clearance being the optimal predictor of ABT-594 clearance.