Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Jun 2004
Randomized Controlled Trial Clinical TrialInfluence of a lipase inhibitor on gastric sensitivity and accommodation to an orally ingested meal.
Intraduodenal administration of lipids, through lipid digestion and release of cholecystokinin (CCK), induces viscero-visceral reflexes that affect gastric tone and sensitivity. It is unclear whether the same mechanisms control gastric function after an orally ingested meal. ⋯ Administration of a lipase inhibitor does not affect gastric compliance, sensitivity to distension and accommodation to an orally ingested meal, and does not influence meal-induced satiety.