Alimentary pharmacology & therapeutics
-
Aliment. Pharmacol. Ther. · Aug 2008
Randomized Controlled TrialClinical trial: effectiveness of chewing-gum in accelerating capsule endoscopy transit time--a prospective randomized, controlled pilot study.
Capsule endoscopy (CE) fails to reach the caecum in approximately 20% of patients. Data suggest that chewing-gum, simulating sham feeding, provokes the cephalic phase of gastrointestinal (GI) motor response and may increase GI motility. ⋯ Chewing-gum significantly reduces GTT and SBTT during CE. Its use may improve the likelihood of the capsule reaching the caecum without affecting CE image quality.
-
Aliment. Pharmacol. Ther. · Aug 2008
Randomized Controlled Trial Multicenter StudyClinical trial: alvimopan for the management of post-operative ileus after abdominal surgery: results of an international randomized, double-blind, multicentre, placebo-controlled clinical study.
Post-operative ileus (POI) affects most patients undergoing abdominal surgery. ⋯ Although the significant clinical effect of alvimopan on reducing POI observed in previous trials was not reproduced, this trial suggests potential benefit in bowel resection patients who received PCA.