Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Sep 2009
ReviewReview article: the current and evolving treatment of colonic diverticular disease.
Formation of colonic diverticula, via herniation of the colonic wall, is responsible for the development of diverticulosis and consequently diverticular disease. Diverticular disease can be associated with numerous debilitating abdominal and gastrointestinal symptoms (including pain, bloating, nausea, constipation and diarrhoea). ⋯ Data suggest that diverticular disease may share many of the hallmarks of other, better-characterized inflammatory bowel diseases; however, treatment options for patients with diverticular disease are scarce, revolving around antibiotic treatment and surgery. There is a need for a better understanding of the fundamental mechanisms of diverticular disease to design treatment regimens accordingly.
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Aliment. Pharmacol. Ther. · Sep 2009
ReviewSystematic review: hepatitis-associated aplastic anaemia--a syndrome associated with abnormal immunological function.
Hepatitis-associated aplastic anaemia is a syndrome in which marrow failure follows the development of hepatitis. ⋯ Hepatitis-associated bone marrow aplasia is mediated by immunological mechanisms. Treatment options include hematopoietic cell transplantation and immunosuppressive therapy.
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Aliment. Pharmacol. Ther. · Sep 2009
ReviewSystematic review: hepatitis-associated aplastic anaemia--a syndrome associated with abnormal immunological function.
Hepatitis-associated aplastic anaemia is a syndrome in which marrow failure follows the development of hepatitis. ⋯ Hepatitis-associated bone marrow aplasia is mediated by immunological mechanisms. Treatment options include hematopoietic cell transplantation and immunosuppressive therapy.