Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Jan 2013
Randomized Controlled Trial Multicenter StudyRandomised clinical trials: linaclotide phase 3 studies in IBS-C - a prespecified further analysis based on European Medicines Agency-specified endpoints.
Treatment options that improve overall symptoms of irritable bowel syndrome with constipation (IBS-C) are lacking. ⋯ Linaclotide treatment significantly improved abdominal pain/discomfort and degree-of-relief of IBS-C symptoms compared with placebo over 12 and 26 weeks.