Alimentary pharmacology & therapeutics
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Aliment. Pharmacol. Ther. · Sep 2013
Meta AnalysisMeta-analysis: Lactobacillus GG for treating acute gastroenteritis in children--updated analysis of randomised controlled trials.
The efficacy of each probiotic should be evaluated separately. Previously, we have shown that Lactobacillus GG (LGG) is effective in treating acute gastroenteritis (AGE) in children. ⋯ Lactobacillus GG reduces the duration of diarrhoea. A subset of patients that is more likely to benefit includes subjects treated with a high daily dose of LGG (≥10¹⁰ CFU/day) who are either in-patients or out-patients from geographical Europe. Given the methodological limitations of many of the included trials, the evidence should be viewed with caution.
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Aliment. Pharmacol. Ther. · Sep 2013
Comparative StudyThe management of alcoholic hepatitis: a prospective comparison of scoring systems.
The assessment of alcoholic hepatitis remains controversial. Several scores have been developed or used for this purpose. ⋯ In this single-centre study, a GAHS ≥9 identified patients who may benefit from treatment of alcoholic hepatitis. Intention-to-treat randomised-controlled trials using a GAHS ≥9 as the threshold for treatment are needed to validate these findings. Response to corticosteroids can be assessed using the Lille Score or by a 25% fall in bilirubin.
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Aliment. Pharmacol. Ther. · Sep 2013
Determinants of long-term outcome in severe alcoholic hepatitis.
Although short-term outcome in severe alcoholic hepatitis (SAH) is well described, its long-term course remains uncharacterised. ⋯ Estimated 5-year survival after index hospitalisation with SAH is 31.8% with alcohol relapse occurring in two-thirds of patients. Abstinence remains the only independent predictor of long-term survival. Novel strategies to improve abstinence after admission with SAH are urgently needed.