Archives of gynecology and obstetrics
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Arch. Gynecol. Obstet. · Jun 2005
Randomized Controlled TrialTocolysis with atosiban: experience in the management of premature labor before 24 weeks of pregnancy.
Atosiban has been shown to be an effective tocolytic agent with a low rate of side effects during 24 to 33 weeks of gestation. Atosiban acts through selective, competitive inhibition of both oxytocin and vasopressin, so that there are reasons to assume that a tocolytic effect can also be achieved earlier in the pregnancy. ⋯ In summary, atosiban showed itself to be effective for tocolytic treatment for premature labor, even during 18 and 24 weeks of pregnancy, while exhibiting its known, favorable profile of side effects.