Archives of gynecology and obstetrics
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Arch. Gynecol. Obstet. · Jul 2013
Randomized Controlled TrialUltrasound-guided transversus abdominal plane block with multimodal analgesia for pain management after total abdominal hysterectomy.
Transversus abdominis plane (TAP) block has been shown to provide pain relief after abdominal procedures. However, TAP block combined with multimodal analgesia technique have not been assessed in a randomized controlled trial. This randomized, controlled, observer-blinded study was designed to evaluate the analgesic efficacy of bilateral ultrasound-guided TAP blocks with or without acetaminophen and non-steroidal anti-inflammatory drug (NSAID) combination. ⋯ The combination of TAP block and acetaminophen and NSAID provided less variability in dynamic pain compared with either treatment alone.
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Arch. Gynecol. Obstet. · Jul 2013
Randomized Controlled Trial Comparative StudyEfficacy of combined metformin-letrozole in comparison with bilateral ovarian drilling in clomiphene-resistant infertile women with polycystic ovarian syndrome.
To compare the hormonal-metabolic profiles and reproductive outcomes between women receiving metformin plus letrozole and women undergoing bilateral ovarian drilling in clomiphene citrate (CC)-resistant women with polycystic ovary syndrome (PCOS). ⋯ Both metformin plus letrozole and bilateral ovarian drilling are similarly effective as second-line strategies for the treatment of women with PCOS who do not conceive with CC.
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Arch. Gynecol. Obstet. · May 2013
Randomized Controlled Trial Comparative StudyComparison the effects of oxytocin and methylergonovine in elective caesarean section under spinal anesthesia.
In order to prevent postpartum hemorrhage in caesarean section under spinal anesthesia, patients routinely receive oxytocin. In this study we compared the efficacy of Methylergonovine and Oxytocin on hemodynamic stability and bleeding amount in caesarean section. ⋯ Methylergonovine induced significantly more hemodynamic stability. Adverse effects were similar between two groups. We recommend the use of methylergonovine in patients with caesarean section under spinal anesthesia because of its hemodynamic stability and low need to vasoconstrictor drugs.
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Arch. Gynecol. Obstet. · Apr 2013
Randomized Controlled TrialTranexamic acid for cesarean section: a double-blind, placebo-controlled, randomized clinical trial.
To assess the efficacy and safety of an intravenous formulation of tranexamic acid to reduce intrapartum and postpartum bleeding in patients giving birth by cesarean section. ⋯ This study confirms that tranexamic acid is effective in reducing intrapartum and postpartum bleeding in patients giving birth by cesarean section. Although some obstetricians are still worried about its thrombosis risk, our study shows that it can be used safely in aforementioned patients.
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Arch. Gynecol. Obstet. · Mar 2013
Randomized Controlled TrialTranexamic acid for the prevention of postpartum hemorrhage after cesarean section: a double-blind randomization trial.
Our purpose in conducting this study was to determine the efficacy of tranexamic acid (TXA) in reducing blood loss in patients after cesarean section (CS). ⋯ Treatment with TXA is effective in reducing blood loss in patients undergoing CS. Although the study was not adequately powered to address safety issues, the observed side effects were mild and transient.