Brain injury : [BI]
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Brain injury : [BI] · Jan 2013
Factor structure of the Depression Anxiety Stress Scales in individuals with traumatic brain injury.
The Depression Anxiety Stress Scales (DASS) and its shorter version, the DASS21, demonstrate a consistent factor structure. However, when these scales are used with people with traumatic brain injury (TBI), it is possible that TBI symptoms that overlap with anxiety and depression (e.g., irritability, inertia, emotional lability) result in changes to the underlying structure. This study aimed to establish whether the factor structure of the DASS and DASS21 when used with individuals with TBI is consistent with the three scales designated in the manual. ⋯ These results indicate that it may be preferable to use the full DASS, rather than the DASS21, with individuals with TBI.
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Brain injury : [BI] · Jan 2013
Acute global outcome in patients with mild uncomplicated and complicated traumatic brain injury.
This study assesses the influence of socio-demographic, psychosocial, clinical and radiological variables on the outcome of patients with mild traumatic brain injury (MTBI) in an acute care inpatient setting. ⋯ This study can help healthcare professionals in treating and planning future care of patients with MTBI.
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Brain injury : [BI] · Jan 2013
Changes in intrinsic functional brain networks following blast-induced mild traumatic brain injury.
Blast-induced mild traumatic brain injuries (mTBI) commonly go undetected by computed tomography and conventional magnetic resonance imaging (MRI). This study was used to investigate functional brain network abnormalities in a group of blast-induced mTBI subjects using independent component analysis (ICA) of resting state functional MRI (fMRI) data. ⋯ The results suggest white matter disruption across certain attentional networks. Additionally, given their elevated activity relative to controls', the temporo-parietal junctions of blast mTBI subjects may be compensating for diffuse axonal injury in other cortical regions.
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Brain injury : [BI] · Jan 2013
Obestatin alleviates subarachnoid haemorrhage-induced oxidative injury in rats via its anti-apoptotic and antioxidant effects.
The aim was to investigate the putative anti-inflammatory and anti-apoptotic effect of obestatin in a rat model of subarachnoidal haemorrhage (SAH). ⋯ The present study provides the first evidence that peripheral administration of obestatin exerts potent anti-inflammatory and neuroprotective effects in SAH-induced oxidative damage by maintaining a balance in oxidant-antioxidant status through the augmentation of endogenous antioxidants and the inhibition of pro-inflammatory mediators.