Brain injury : [BI]
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Brain injury : [BI] · Jan 2013
Randomized Controlled TrialEffect of COMT Val158Met genotype on attention and response to methylphenidate following traumatic brain injury.
To investigate whether COMT Val158Met allele status was associated with (i) attentional performance and (ii) response to methylphenidate (MP) following traumatic brain injury (TBI). ⋯ COMT allele status was not strongly associated with attentional performance or response to MP in the TBI sample. The met/met group, whilst performing slowly, had relatively preserved strategic control of attention.
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Brain injury : [BI] · Jan 2013
Randomized Controlled Trial Comparative StudyEffect of frequency of multimodal coma stimulation on the consciousness levels of traumatic brain injury comatose patients.
To evaluate the effectiveness of multimodal coma stimulation on the conscious levels of head injury comatose patients and to find out which of the two protocols of coma stimulation, i.e. administrating twice a day or 5-times a day is more beneficial. ⋯ The results showed a significant difference (p < 0.01) for Glasgow Coma Scale as well as Western Neuro Sensory Stimulation Profile scores between Groups A & C and B & C, i.e. multimodal coma stimulation is effective as compared to the control group. The results also revealed a significant difference (p < 0.01) between Groups A, B and C on the Western Neuro Sensory Stimulation Profile but a non-significant difference (p > 0.01) on the Glasgow coma scale. This indicates that short sessions of high frequency can be more beneficial.