Brain injury : [BI]
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Brain injury : [BI] · Jan 2014
ReviewWhere are we in the modelling of traumatic brain injury? Models complicated by secondary brain insults.
Traumatic brain injury (TBI) contributes to a substantial number of deaths and cases of disability. Despite well-established experimental models and years of carefully conducted research, a clinical therapeutic breakthrough in TBI has lagged. This may be due, in part, to the discrepancies between commonly used experimental models and clinical scenarios. ⋯ A more complete understanding of the interactions between the injured brain and secondary insults represents a potentially fruitful avenue that may increase the likelihood of developing effective therapies. Experimental models of TBI should not only attempt to model the focal or diffuse changes resulting from external forces, but also integrate, when appropriate, secondary insults reminiscent of human situations.
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Brain injury : [BI] · Jan 2014
Comparative StudyHospital admissions for traumatic brain injury of Austrian residents vs. of visitors to Austria.
The goal was to compare epidemiology of hospital admissions for traumatic brain injury (TBI) in Austrian residents vs. visitors to Austria. ⋯ Sports-related TBI of visitors causes a significant workload for Austrian hospitals. Better prevention is warranted.
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Brain injury : [BI] · Jan 2014
Comparative StudyComparison of several prognostic tools in traumatic brain injury including S100B.
To identify which tool (a model, a biomarker or a combination of these) has better prognostic strength in traumatic brain injury (TBI). ⋯ A better prognostic tool than those currently available may be a combination of clinical predictors with a biomarker.
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To determine the usefulness of S-100β, a marker for central nervous system damage, in the prediction of long-term outcomes after mild traumatic brain injury (MTBI) Hypothesis: Mid- and long-term outcomes of MTBI (i.e. 3, 6 and 12 months post-injury and return-to-work or school (RTWS)) may be predicted based on pre-injury and injury factors as well as S-100β. ⋯ Amongst MTBI patients, S-100β levels are not associated with prolonged post-concussive syndrome or the inability to RTWS.
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Brain injury : [BI] · Jan 2014
Randomized Controlled Trial Comparative StudySingle versus bilateral external ventricular drainage for intraventricular fibrinolysis using urokinase in severe ventricular haemorrhage.
Intraventricular fibrinolysis (IVF) through bilateral external ventricular drains (EVD) may provide better access of the thrombolytic agent to the intraventricular clot, potentially leading to faster clot clearance. ⋯ The results provide some evidence to support the use of bilateral EVDs for IVF in patients with severe IVH.