Brain injury : [BI]
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Brain injury : [BI] · Jan 2012
Randomized Controlled TrialProstacyclin treatment and clinical outcome in severe traumatic brain injury patients managed with an ICP-targeted therapy: a prospective study.
To prospectively assess clinical outcome in patients with severe traumatic brain injury (sTBI) managed according to an ICP-targeted programme as well as additional treatment with prostacyclin. ⋯ With this treatment protocol, a low number of deaths and a high number of favourable outcomes in sTBI were observed. Prostacyclin in this low dose does not seem to improve the outcome. ICP(max) is a positive predictor of worse outcome. Higher GCS at admission and lower age are correlated to better outcome.
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Brain injury : [BI] · Sep 2008
Randomized Controlled Trial Multicenter StudyA French validation study of the Coma Recovery Scale-Revised (CRS-R).
The aim of the present study was to explore the concurrent validity, inter-rater agreement and diagnostic sensitivity of a French adaptation of the Coma Recovery Scale-Revised (CRS-R) as compared to other coma scales such as the Glasgow Coma Scale (GCS), the Full Outline of UnResponsiveness scale (FOUR) and the Wessex Head Injury Matrix (WHIM). ⋯ The results show that the French version of the CRS-R is a valid and sensitive scale which can be used in severely brain damaged patients by all members of the medical staff.
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Brain injury : [BI] · Oct 2001
Randomized Controlled Trial Clinical TrialPilot study of electrical stimulation on median nerve in comatose severe brain injured patients: 3-month outcome.
To determine if electrical stimulation (ES) benefits (waking time, 3-month outcomes) treated coma patients. ⋯ These data show an interesting trend, although statistical power was limited in this small pilot study, suggesting the need for a larger trial.
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Brain injury : [BI] · Nov 1999
Randomized Controlled Trial Clinical TrialCognitive and behavioural efficacy of amantadine in acute traumatic brain injury: an initial double-blind placebo-controlled study.
The objective of the current study was to determine the efficacy of amantadine in improving cognitive and behavioural performance in a traumatic brain injury (TBI) rehabilitation sample. The design was a prospective, randomized, double-blind, placebo-controlled, crossover design. Subjects were 10 adult traumatic brain injury patients in an acute brain injury rehabilitation unit. ⋯ In conclusion, although patients generally improved, this initial exploratory study found no differences in rate of cognitive improvement between subjects given amantadine versus those given placebo. However, the small sample size, heterogeneous population, acute time course, and large number of dependent variables limit power and generalizability. Implications are discussed for further research to better answer questions regarding efficacy of amantadine post-TBI.