Toxicology
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Comparative Study
Methodologic considerations in the interpretation of postmortem carboxyhemoglobin concentrations.
The interpretation of postmortem carboxyhemoglobin (COHb) concentrations can have major implications even when COHb is not the direct cause of death. Much litigation may hinge on the length of time an individual was alive during the fire. Therefore, the reliability of an analytical method to measure COHb, ranging from low to sub-lethal levels, is critical to the proper interpretation of results. ⋯ At GC COHb levels ranging from 5 to 40% and Hb > or = 4g/dl, the average and median ratios were 1.6 and 1.0 respectively. These ratios were correspondingly 2.1 and 1.9 when Hb < 4 g/dl. These data clearly indicate COHb can be influenced by the analytical methods used.