Journal of clinical epidemiology
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Multicenter Study
The trials within cohorts design facilitated efficient patient enrollment and generalizability in oncology setting.
The trials within cohorts (TwiCs) design aims to improve recruitment efficiency. We conducted the first TwiCs in radiation oncology and described efficiency of the design and generalizability of the results. ⋯ The TwiCs design is feasible, allows enrollment of a high proportion of randomizable patients, with positive impact on trial efficiency and generalizability of results in a clinical oncology setting.