Clinical rehabilitation
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Clinical rehabilitation · Sep 2012
Randomized Controlled Trial Multicenter StudyA prospective, multicentre, randomized, double-blind, placebo-controlled trial of onabotulinumtoxinA to treat plantarflexor/invertor overactivity after stroke.
To examine the safety and efficacy of onabotulinumtoxinA (Botox) for plantarflexor overactivity following stroke. ⋯ OnabotulinumtoxinA injection for ankle flexor overactivity after stroke was safe and well tolerated but did not alter local spasticity at 12 weeks; it did reduce spasms and improve gait quality. There were no detectable differences between higher and lower doses. A second injection may be associated with greater change.