Reproductive toxicology
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Reproductive toxicology · Apr 2015
Review Meta AnalysisExposure to fluconazole and risk of congenital malformations in the offspring: A systematic review and meta-analysis.
Vulvovaginal candidiasis (VVC) affects up to 75% of women at least once during their lifetime, mostly during the reproductive age, and recurrence rate is about 50%. Because half of all pregnancies are unplanned and pregnant women have an increased risk of VVC recurrence, the likelihood of inadvertently being exposed to fluconazole in pregnancy is increased. ⋯ In conclusion, the use of fluconazole in the first trimester does not appear to increase the overall risk for congennital malformations. More studies are needed to address the potential increased rate of heart defects.