American journal of hypertension
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Randomized Controlled Trial Comparative Study
Left ventricular responses to acute changes in late systolic pressure augmentation in older adults.
Changes in the cardiovascular system with age may predispose older persons to development of heart failure with preserved ejection fraction. Vascular stiffening, aortic pressure augmentation, and ventricular-vascular coupling have been implicated. We explored the potential for acute reductions in late systolic pressure augmentation to impact left ventricular relaxation in older persons without heart failure. ⋯ This study is registered at clinicaltrials.gov as NCT00204984.