American journal of physical medicine & rehabilitation
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Am J Phys Med Rehabil · Jun 2004
Randomized Controlled Trial Clinical TrialEffects of methylphenidate on attention deficits after traumatic brain injury: a multidimensional, randomized, controlled trial.
To evaluate the effects of methylphenidate on a variety of aspects of attention, ranging from laboratory-based impairment measures to caregiver ratings and work productivity, in individuals after traumatic brain injury. ⋯ Methylphenidate, at 0.3 mg/kg/dose, given twice a day to individuals with attentional complaints after traumatic brain injury, seems to have clinically significant positive effects on speed of processing, caregiver ratings of attention, and some aspects of on-task behavior in naturalistic tasks. Further research is needed to identify the optimal dose and to extend these findings to less carefully selected individuals.